| NCAAB | 11/19 00:00 | - | USC Upstate v East Tennessee State | L | 43-56 | |
| NCAAB | 11/15 23:00 | - | USC Upstate v St. Andrew's | W | 96-43 | |
| NCAAB | 11/13 00:00 | - | [305] USC Upstate v Charlotte [208] | L | 64-76 | |
| NCAAB | 11/10 00:00 | - | USC Upstate v Południowa Karolina | L | 60-78 | |
| NCAAB | 02/27 21:00 | 122 | [331] USC Upstate v High Point [277] | L | 60-65 | |
| NCAAB | 02/22 23:00 | - | Gardner Webb v USC Upstate | L | 69-58 | |
| NCAAB | 02/18 22:00 | - | USC Upstate v Presbyterian | W | 65-51 | |
| NCAAB | 02/15 23:00 | - | USC Upstate v Presbyterian | L | 65-75 | |
| NCAAB | 02/13 00:00 | - | USC Upstate v Campbell | L | 49-64 | |
| NCAAB | 02/12 00:00 | - | USC Upstate v Campbell | L | 71-72 | |
| NCAAB | 02/08 22:00 | - | Gardner Webb v USC Upstate | W | 69-77 | |
| NCAAB | 02/05 23:00 | - | USC Upstate v Radford | L | 66-102 | |
| NCAAB | 02/04 23:00 | - | USC Upstate v Radford | L | 61-63 | |
| NCAAB | 01/20 00:00 | - | USC Upstate v Charleston Southern | D | Postponed | |
| NCAAB | 01/15 23:00 | - |
Hampton
v
USC Upstate
|
L | 84-74 | |
| NCAAB | 01/14 23:00 | - |
Hampton
v
USC Upstate
|
L | 69-68 | |
| NCAAB | 01/05 23:00 | - | Longwood v USC Upstate | W | 59-65 | |
| NCAAB | 01/04 23:00 | - | Longwood v USC Upstate | W | 69-71 | |
| NCAAB | 12/31 23:00 | - | USC Upstate v High Point | W | 60-51 | |
| NCAAB | 12/30 23:00 | - | USC Upstate v High Point | L | 52-63 | |
| NCAAB | 12/23 22:00 | - | USC Upstate v Tennessee | L | 60-80 | |
| NCAAB | 12/16 00:00 | - | USC Upstate v UNC Greensboro | L | 57-65 | |
| NCAAB | 12/13 19:00 | - | Winthrop v USC Upstate | L | 107-77 | |
| NCAAB | 12/12 21:00 | - | Winthrop v USC Upstate | L | 95-77 | |
| NCAAB | 12/05 23:00 | - | Georgia Southern v USC Upstate | L | 72-69 | |
| NCAAB | 12/02 22:30 | - | Eastern Kentucky v USC Upstate | L | 95-78 | |
| NCAAB | 11/28 19:00 | - | USC Upstate v Furman | L | 63-91 | |
| NCAAB | 11/25 19:00 | - | USC Upstate v Southern Wesleyan | L | 72-82 | |
| NCAAB | 03/05 17:00 | 3 | USC Upstate v Winthrop | L | 70-106 | |
| NCAAB | 03/04 00:00 | 122 | High Point v USC Upstate | W | 59-69 |
Drużyna koszykarska USC Upstate to drużyna uczelniana reprezentująca Uniwersytet Południowej Karoliny w miejscowości Upstate w Greenville w Karolinie Południowej. Rywalizują w NCAA Division I jako członkowie Konferencji Big South. Mecze domowe rozgrywają w G.B. Hodge Center.