| ATP Indian Wells | 03/11 21:20 | 24 | Ruben Bemelmans v Leonardo Mayer | 4-6,1-6 | |
| ATP Indian Wells | 03/11 21:00 | 24 | Kei Nishikori v Leonardo Mayer | View | |
| ATP Indian Wells | 03/10 01:35 | 23 | Leonardo Mayer v Victor Estrella Burgos | 4-6,6-4,6-1 | |
| ATP Sao Paulo | 03/02 15:30 | 27 | Leonardo Mayer v Pablo Cuevas | 2-6,7-6,6-7 | |
| ATP Sao Paulo | 02/28 15:30 | 26 | Leonardo Mayer v Carlos Berlocq | 7-5,6-4 | |
| ATP Sao Paulo | 02/26 19:45 | 25 | Leonardo Mayer v Gastao Elias | 5-7,7-6,7-6 | |
| ATP Rio De Janeiro | 02/19 21:30 | 25 | Fernando Verdasco v Leonardo Mayer | 6-2,3-6,6-3 | |
| ATP Buenos Aires | 02/16 21:45 | 27 | Leonardo Mayer v Gael Monfils | 4-6,6-3,3-6 | |
| ATP Buenos Aires | 02/16 00:40 | 26 | Fabio Fognini v Leonardo Mayer | 3-6,3-6 | |
| ATP Buenos Aires | 02/13 17:00 | 25 | Rogerio Dutra Silva v Leonardo Mayer | 7-6,2-6,4-6 | |
| Australian Open | 01/17 05:30 | 24 | Rafael Nadal v Leonardo Mayer | 6-3,6-4,7-6 | |
| Australian Open | 01/15 07:00 | 23 | Nicolas Jarry v Leonardo Mayer | 2-6,6-7,3-6 | |
| ATP Sydney | 01/10 03:20 | 26 | Leonardo Mayer v Benoit Paire | 2-6,6-3,1-6 | |
| ATP Sydney | 01/09 01:00 | 25 | Mischa Zverev v Leonardo Mayer | 5-7,3-6 | |
| ATP Brisbane | 01/01 01:00 | 25 | Ryan Harrison v Leonardo Mayer | 6-4,3-6,6-2 | |
| ATP - Bazylea | 10/26 11:00 | 26 | Leonardo Mayer v Marton Fucsovics | Retired | |
| ATP - Bazylea | 10/24 13:00 | 25 | [30] Mischa Zverev v Leonardo Mayer [52] | 5-7,5-7 | |
| ATP Sztokholm | 10/17 16:30 | 25 | [53] Leonardo Mayer v Elias Ymer [202] | 4-6,6-3,5-7 | |
| ATP Shanghai Qual | 10/08 06:05 | 46 | [54] Leonardo Mayer v Frances Tiafoe [74] | 6-4,4-6,4-6 | |
| ATP Shanghai Qual | 10/07 05:20 | 45 | [54] Leonardo Mayer v Sergiy Stakhovsky [103] | 7-6,3-6,7-6 | |
| ATP Pekin | 10/05 06:30 | 26 | [54] Leonardo Mayer v John Isner [17] | 0-6,3-6 | |
| ATP Pekin | 10/03 05:50 | 25 | [54] Leonardo Mayer v Paolo Lorenzi [38] | 7-6,5-7,6-4 | |
| ATP Chengdu | 09/27 05:00 | 25 | [66] Peter Gojowczyk v Leonardo Mayer [54] | 6-2,6-2 | |
| US Open | 09/02 21:10 | 25 | [1] Rafael Nadal v Leonardo Mayer [59] | 6-7,6-3,6-1,6-4 | |
| US Open | 08/31 21:35 | 24 | [44] Yuichi Sugita v Leonardo Mayer [59] | 7-6,4-6,3-6,4-6 | |
| US Open | 08/29 15:00 | 23 | [59] Leonardo Mayer v Richard Gasquet [30] | 3-6,6-2,6-4,6-2 | |
| US Open Qual | 08/25 15:00 | 46 | [52] Leonardo Mayer v Maximilian Marterer [124] | 4-6,5-7 | |
| US Open Qual | 08/24 15:00 | 45 | [52] Leonardo Mayer v Gleb Sakharov [190] | 6-2,6-1 | |
| US Open Qual | 08/22 17:55 | 44 | [52] Leonardo Mayer v Maxime Janvier [235] | 6-4,6-4 | |
| Challenger Biella | 08/01 13:00 | 25 | Leonardo Mayer v Maxime Janvier | Cancelled |