| NCAAF | 11/11 18:00 | 1 | Greenville Panthers v Crown Storm | W | 64-20 | |
| NCAAF | 11/04 00:00 | 1 | Greenville Panthers v Kalamazoo Hornets | L | 23-33 | |
| NCAAF | 10/28 17:00 | 1 | Westminster Blue Jays v Greenville Panthers | W | 6-38 | |
| NCAAF | 10/21 17:00 | 1 | Greenville Panthers v Northwestern Eagles | L | 12-32 | |
| NCAAF | 10/14 17:00 | 1 | Martin Luther Knights v Greenville Panthers | L | 31-29 | |
| NCAAF | 09/30 17:00 | 1 | Greenville Panthers v Minnesota Morris Cougars | L | 10-24 | |
| NCAAF | 09/23 17:00 | 1 |
Greenville Panthers
v
Adrian Bulldogs
|
W | 45-35 | |
| NCAAF | 09/16 17:00 | 1 | Manchester Spartans v Greenville Panthers | W | 7-59 | |
| NCAAF | 09/09 17:00 | 1 | Greenville Panthers v Eureka Red Devils | L | 14-23 | |
| NCAAF | 09/02 18:00 | 1 | Concordia Chicago Cougars v Greenville Panthers | W | 14-41 | |
| NCAAF | 11/12 18:00 | 1 | Minnesota Morris Cougars v Greenville Panthers | W | 25-43 | |
| NCAAF | 11/05 17:00 | 1 | Greenville Panthers v Finlandia Lions | W | 45-7 | |
| NCAAF | 10/29 20:00 | 1 | Crown Storm v Greenville Panthers | W | 6-48 | |
| NCAAF | 10/15 18:00 | 1 | Greenville Panthers v Westminster Blue Jays | W | 52-0 | |
| NCAAF | 10/08 17:00 | 1 | Northwestern Eagles v Greenville Panthers | L | 41-35 | |
| NCAAF | 10/01 17:00 | 1 | Greenville Panthers v Martin Luther Knights | W | 30-27 | |
| NCAAF | 09/24 18:00 | 1 | Greenville Panthers v Olivet Comets | L | 7-63 | |
| NCAAF | 09/17 18:00 | 1 | Greenville Panthers v Manchester Spartans | W | 49-22 | |
| NCAAF | 09/10 18:00 | 1 | Greenville Panthers v Rockford Regents | W | 40-30 | |
| NCAAF | 09/03 18:00 | 1 | Millikin Big Blue v Greenville Panthers | L | 28-14 | |
| NCAAF | 11/20 18:00 | 7 | UW-Whitewater v Greenville Panthers | L | 69-7 | |
| NCAAF | 11/13 18:00 | 1 | Greenville Panthers v Minnesota Morris Cougars | W | 47-21 | |
| NCAAF | 11/06 17:00 | 1 | Finlandia Lions v Greenville Panthers | W | 2-28 | |
| NCAAF | 10/30 18:00 | 1 | Greenville Panthers v Crown Storm | W | 55-30 | |
| NCAAF | 10/16 18:00 | 1 | Westminster Blue Jays v Greenville Panthers | W | 14-42 | |
| NCAAF | 10/09 17:00 | 1 | Greenville Panthers v Northwestern Eagles | W | 35-23 | |
| NCAAF | 10/02 17:00 | 1 | Martin Luther Knights v Greenville Panthers | W | 14-21 | |
| NCAAF | 09/25 18:00 | 1 | Trinity I. Trojans v Greenville Panthers | L | 26-21 | |
| NCAAF | 09/18 19:00 | 1 |
Adrian Bulldogs
v
Greenville Panthers
|
L | 41-28 | |
| NCAAF | 09/11 19:30 | 1 | Rockford Regents v Greenville Panthers | W | 42-57 |