Stadium: Harry Turpin Stadium Round: 1
Home Manager: Brad Laird Away Manager: Tom Matukewicz
| NCAAF | 2022/10/08 19:00 | Tennessee Tech v SE Missouri St | W | 20-34 |
| NCAAF | 2022/10/01 18:00 | SE Missouri St v Lindenwood | W | 49-28 |
| NCAAF | 2022/09/24 19:00 | Central Arkansas v SE Missouri St | W | 27-35 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | W | 16-42 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | W | 34-31 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | L | 10-42 |
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | W | 14-31 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | L | 10-28 |
| NCAAF | 2022/10/15 23:00 | Northwestern State v Houston Christian | W | 37-10 |
| NCAAF | 2022/10/08 19:00 | Northwestern State v Eastern Illinois | L | 27-35 |
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | W | 33-36 |
| NCAAF | 2022/09/24 20:30 | Lamar v Northwestern State | W | 27-35 |
| NCAAF | 2022/09/17 23:00 | Northwestern State v Southern Mississippi | L | 10-64 |
| NCAAF | 2022/09/10 23:00 | Grambling State v Northwestern State | L | 47-21 |
| NCAAF | 2022/09/03 19:00 | Northwestern State v Montana | L | 0-47 |
| NCAAF | 2021/11/20 18:00 | Northwestern State v McNeese State | W | 24-20 |