[14] Louisville 16-31 Clemson [1] 2022-11-12 20:30
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | L | 45-10 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | L | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | L | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | L | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | L | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | L | 23-17 |
Home History
| NCAAF | 2022/11/05 23:30 | James Madison v Louisville | W | 10-34 |
| NCAAF | 2022/10/29 19:30 | Wake Forest v Louisville | W | 21-48 |
| NCAAF | 2022/10/23 00:00 | Pittsburgh v Louisville | W | 10-24 |
| NCAAF | 2022/10/08 16:00 | Louisville v Virginia | W | 34-17 |
| NCAAF | 2022/10/01 16:00 | Louisville v Boston College | L | 33-34 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
Away History
| NCAAF | 2022/11/05 23:30 | Clemson v Notre Dame | L | 14-35 |
| NCAAF | 2022/10/22 16:00 | Syracuse v Clemson | W | 21-27 |
| NCAAF | 2022/10/15 23:30 | Clemson v Florida State | W | 34-28 |
| NCAAF | 2022/10/08 23:30 | Clemson v Boston College | W | 31-3 |
| NCAAF | 2022/10/01 23:30 | NC State v Clemson | W | 20-30 |
| NCAAF | 2022/09/24 16:00 | Clemson v Wake Forest | W | 51-45 |
| NCAAF | 2022/09/18 00:00 | Louisiana Tech v Clemson | W | 20-48 |
| NCAAF | 2022/09/10 19:30 | Furman v Clemson | W | 12-35 |