[11] Clemson 51-45 Wake Forest [25] 2022-09-24 16:00
Stadium: Allegacy Federal Credit Union Stadium Round: 1
Home Manager: Dave Clawson Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2020/09/12 23:30 | Clemson v Wake Forest | W | 37-13 |
| NCAAF | 2019/11/16 20:30 | Wake Forest v Clemson | W | 3-52 |
| NCAAF | 2018/10/06 19:30 | Clemson v Wake Forest | W | 63-3 |
| NCAAF | 2017/10/07 16:00 | Wake Forest v Clemson | W | 14-28 |
| NCAAF | 2016/11/20 00:00 | Clemson v Wake Forest | W | 35-13 |
| NCAAF | 2015/11/21 20:30 | Clemson v Wake Forest | W | 33-13 |
| NCAAF | 2014/11/07 00:30 | Wake Forest v Clemson | W | 20-34 |
Home History
| NCAAF | 2022/09/18 00:00 | Louisiana Tech v Clemson | W | 20-48 |
| NCAAF | 2022/09/10 19:30 | Furman v Clemson | W | 12-35 |
| NCAAF | 2022/09/06 00:00 | Clemson v Georgia Tech | W | 41-10 |
| NCAAF - Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | W | 13-20 |
| NCAAF | 2021/11/28 00:30 | Clemson v Południowa Karolina | W | 30-0 |
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
Away History
| NCAAF | 2022/09/17 21:00 | Liberty v Wake Forest | W | 36-37 |
| NCAAF | 2022/09/10 16:00 | Wake Forest v Vanderbilt | W | 45-25 |
| NCAAF | 2022/09/01 23:30 | VMI v Wake Forest | W | 10-44 |
| NCAAF - Bowl Games | 2021/12/31 16:00 | Rutgers v Wake Forest | W | 10-38 |
| NCAAF | 2021/12/05 01:00 | Wake Forest v Pittsburgh | L | 21-45 |
| NCAAF | 2021/11/27 17:00 | Wake Forest v Boston College | W | 41-10 |
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | L | 27-48 |
| NCAAF | 2021/11/14 00:30 | NC State v Wake Forest | W | 42-45 |