Stadium: Fitton Field Round: 1
Home Manager: Bob Chesney Away Manager: Mark Nofri
| NCAAF | 2021/11/20 17:00 | Sacred Heart v LIU Brooklyn | W | 38-14 |
| NCAAF | 2021/11/13 17:00 | Wagner v Sacred Heart | W | 0-27 |
| NCAAF | 2021/11/06 16:00 | Sacred Heart v St.Francis (PA) | W | 14-13 |
| NCAAF | 2021/10/23 16:00 | Duquesne v Sacred Heart | W | 13-31 |
| NCAAF | 2021/10/16 17:00 | Central Connecticut v Sacred Heart | W | 17-27 |
| NCAAF | 2021/10/09 18:00 | Merrimack v Sacred Heart | W | 10-20 |
| NCAAF | 2021/10/02 17:00 | Sacred Heart v Howard | L | 17-22 |
| NCAAF | 2021/09/25 17:30 | Sacred Heart v Dartmouth | L | 3-41 |
| NCAAF | 2021/11/20 18:00 | Holy Cross v Bucknell | W | 45-6 |
| NCAAF | 2021/11/13 18:00 | Holy Cross v Fordham | W | 52-24 |
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | W | 10-35 |
| NCAAF | 2021/10/30 16:00 | Holy Cross v Lehigh | W | 31-12 |
| NCAAF | 2021/10/23 21:00 | Colgate v Holy Cross | W | 10-42 |
| NCAAF | 2021/10/16 17:30 | Georgetown v Holy Cross | W | 14-48 |
| NCAAF | 2021/10/02 17:30 | Harvard v Holy Cross | L | 38-13 |
| NCAAF | 2021/09/25 17:00 | Holy Cross v Monmouth | W | 45-15 |