[44] Clemson 17-27 Pittsburgh [20] 2021-10-23 19:30
Stadium: Heinz Field Round: 1
Home Manager: Pat Narduzzi Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | W | 17-52 |
| NCAAF | 2018/12/02 01:00 | Pittsburgh v Clemson | W | 10-42 |
| NCAAF | 2016/11/12 20:30 | Pittsburgh v Clemson | L | 43-42 |
Home History
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | W | 13-19 |
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | L | 21-27 |
| NCAAF | 2021/09/18 19:30 | Georgia Tech v Clemson | W | 8-14 |
| NCAAF | 2021/09/11 21:00 | South Carolina State v Clemson | W | 3-49 |
| NCAAF | 2021/09/04 23:30 | Georgia v Clemson | L | 10-3 |
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | W | 34-10 |
Away History
| NCAAF | 2021/10/16 19:30 | Pittsburgh v Virginia Tech | W | 28-7 |
| NCAAF | 2021/10/02 16:00 | Pittsburgh v Georgia Tech | W | 52-21 |
| NCAAF | 2021/09/25 16:00 | New Hampshire v Pittsburgh | W | 7-77 |
| NCAAF | 2021/09/18 16:00 | Western Michigan v Pittsburgh | L | 44-41 |
| NCAAF | 2021/09/11 16:00 | Pittsburgh v Tennessee | W | 41-34 |
| NCAAF | 2021/09/04 20:00 | Massachusetts v Pittsburgh | W | 7-51 |
| NCAAF | 2020/12/11 00:00 | Pittsburgh v Georgia Tech | W | 34-20 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | L | 17-52 |