Stadium: Polar Park Round: 1
Home Manager: Bob Chesney Away Manager:
| NCAAF | 2019/10/26 17:00 | Colgate v Holy Cross | L | 10-31 |
| NCAAF | 2018/09/01 17:00 | Holy Cross v Colgate | W | 17-24 |
| NCAAF | 2017/10/21 16:05 | Holy Cross v Colgate | W | 7-45 |
| NCAAF | 2021/10/15 23:00 | Colgate v Cornell Big Red | L | 20-34 |
| NCAAF | 2021/10/09 16:30 | Colgate v Brown | L | 10-31 |
| NCAAF | 2021/10/02 16:30 | Colgate v Georgetown | W | 28-21 |
| NCAAF | 2021/09/25 17:00 | Lehigh v Colgate | W | 3-30 |
| NCAAF | 2021/09/18 17:00 | William & Mary v Colgate | L | 27-7 |
| NCAAF | 2021/09/11 17:00 | Stony Brook v Colgate | L | 24-3 |
| NCAAF | 2021/09/04 16:00 | Colgate v Boston College | L | 0-51 |
| NCAAF | 2021/04/03 20:00 | Colgate v Fordham | L | 8-40 |
| NCAAF | 2021/10/16 17:30 | Georgetown v Holy Cross | W | 14-48 |
| NCAAF | 2021/10/02 17:30 | Harvard v Holy Cross | L | 38-13 |
| NCAAF | 2021/09/25 17:00 | Holy Cross v Monmouth | W | 45-15 |
| NCAAF | 2021/09/18 16:00 | Holy Cross v Yale | W | 20-17 |
| NCAAF | 2021/09/11 18:00 | Merrimack v Holy Cross | L | 35-21 |
| NCAAF | 2021/09/04 16:00 | Holy Cross v Connecticut | W | 38-28 |
| NCAAF | 2021/04/24 19:00 | Holy Cross v South Dakota State | L | 3-31 |
| NCAAF | 2021/04/17 18:00 | Holy Cross v Bucknell | W | 33-10 |