[4] RB Leipzig 1-2 Club Brugge [3] 2021-09-28 19:00
Stadium: Red Bull Arena Round: 2
Referee: Slavko Vincic Home Manager: Jesse Marsch Away Manager: Philippe Clement
Home History
| Niemcy - Bundesliga I | 2021/09/25 13:30 | RB Leipzig v Hertha Berlin | W | 6-0 |
| Niemcy - Bundesliga I | 2021/09/18 16:30 | FC Köln v RB Leipzig | D | 1-1 |
| Liga Mistrzów UEFA | 2021/09/15 19:00 | Man City v RB Leipzig | L | 6-3 |
| Niemcy - Bundesliga I | 2021/09/11 16:30 | RB Leipzig v Bayern Monachium | L | 1-4 |
| Niemcy - Bundesliga I | 2021/08/29 15:30 | Wolfsburg v RB Leipzig | L | 1-0 |
| Niemcy - Bundesliga I | 2021/08/20 18:30 | RB Leipzig v VfB Stuttgart | W | 4-0 |
| Niemcy - Bundesliga I | 2021/08/15 13:30 | Mainz v RB Leipzig | L | 1-0 |
| Puchar Niemiec | 2021/08/07 13:30 | Sandhausen v RB Leipzig | W | 0-4 |
Away History
| Belgia - First Division A | 2021/09/24 18:45 | Club Brugge v OH Leuven | D | 1-1 |
| Belgia - First Division A | 2021/09/18 18:45 | Charleroi v Club Brugge | W | 0-1 |
| Liga Mistrzów UEFA | 2021/09/15 19:00 | Club Brugge v PSG | D | 1-1 |
| Belgia - First Division A | 2021/09/10 18:45 | Club Brugge v KV Oostende | W | 3-0 |
| Belgia - First Division A | 2021/08/29 11:30 | Gent v Club Brugge | L | 6-1 |
| Belgia - First Division A | 2021/08/22 16:30 | Club Brugge v KFCO Beerschot Wilrijk | W | 3-2 |
| Belgia - First Division A | 2021/08/15 19:00 | Zulte-Waregem v Club Brugge | W | 0-4 |
| Belgia - First Division A | 2021/08/06 18:45 | Club Brugge v Cercle Brugge | D | 1-1 |