[10] Boston College 13-19 Clemson [74] 2021-10-02 23:30
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Jeff Hafley
Head to Head
| NCAAF | 2020/10/31 16:00 | Boston College v Clemson | L | 28-34 |
| NCAAF | 2019/10/26 23:30 | Clemson v Boston College | L | 59-7 |
| NCAAF | 2018/11/11 01:00 | Clemson v Boston College | L | 27-7 |
| NCAAF | 2017/09/23 19:30 | Clemson v Boston College | L | 34-7 |
| NCAAF | 2017/09/23 19:30 | Boston College v Clemson | L | 7-34 |
| NCAAF | 2016/10/07 23:30 | Clemson v Boston College | L | 56-10 |
| NCAAF | 2015/10/17 23:00 | Clemson v Boston College | L | 34-17 |
| NCAAF | 2014/10/18 19:30 | Boston College v Clemson | L | 13-17 |
Home History
| NCAAF | 2021/09/25 16:00 | Missouri v Boston College | W | 34-41 |
| NCAAF | 2021/09/18 16:00 | Boston College v Temple | W | 28-3 |
| NCAAF | 2021/09/11 19:30 | Boston College v Massachusetts | W | 45-28 |
| NCAAF | 2021/09/04 16:00 | Colgate v Boston College | W | 0-51 |
| NCAAF | 2020/12/05 20:30 | Boston College v Virginia | L | 32-43 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | W | 27-34 |
| NCAAF | 2020/11/14 20:30 | Notre Dame v Boston College | L | 45-31 |
| NCAAF | 2020/11/07 19:00 | Boston College v Syracuse | W | 16-13 |
Away History
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | L | 21-27 |
| NCAAF | 2021/09/18 19:30 | Georgia Tech v Clemson | W | 8-14 |
| NCAAF | 2021/09/11 21:00 | South Carolina State v Clemson | W | 3-49 |
| NCAAF | 2021/09/04 23:30 | Georgia v Clemson | L | 10-3 |
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | W | 34-10 |
| NCAAF | 2020/12/06 00:30 | Clemson v Virginia Tech | W | 45-10 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | W | 17-52 |